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Document type:
journal article 
Author(s):
Ruppert, C; Mahavadi, P; Wygrecka, M; Weaver, TE; Magdolen, V; Idell, S; Preissner, KT; Seeger, W; Günther, A; Markart, P 
Title:
Recombinant production of a hybrid plasminogen activator composed of surfactant protein B and low-molecular-weight urokinase. 
Abstract:
Intraalveolar fibrin deposition is commonly observed during acute inflammatory and chronic interstitial lung diseases and may contribute to impairment of surfactant function and gas exchange. We recently described a chemically cross-linked chimeric protein consisting of surfactant protein (SP)-B and urokinase (uPA) for targeting alveolar fibrin under conditions such as acute respiratory distress syndrome (ARDS) or lung fibrosis. We now investigated the feasibility of a recombinant production of...    »
 
Journal title abbreviation:
Thromb Haemost 
Year:
2008 
Journal volume:
100 
Journal issue:
Pages contribution:
1185-92 
Language:
eng 
Print-ISSN:
0340-6245 
TUM Institution:
Frauenklinik und Poliklinik