User: Guest  Login
Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Knör, S; Khrenov, A; Laufer, B; Benhida, A; Grailly, SC; Schwaab, R; Oldenburg, J; Beaufort, N; Magdolen, V; Saint-Remy, JM; Saenko, EL; Hauser, CA; Kessler, H
Title:
Efficient factor VIII affinity purification using a small synthetic ligand.
Abstract:
BACKGROUND: Hemophilia A is currently treated by infusions of the coagulation factor (F) VIII, of which production and purification remain a challenging task. Current purification procedures using immunoaffinity chromatography are cumbersome, expensive, and suffer from the instability of the applied antibody ligands, which elute along with the product and contaminate it. Recently, FVIII was purified using octapeptide ligands, but their use is limited due to the low resistance to proteases. OBJEC...     »
Journal title abbreviation:
J Thromb Haemost
Year:
2008
Journal volume:
6
Journal issue:
3
Pages contribution:
470-7
Language:
eng
Fulltext / DOI:
doi:10.1111/j.1538-7836.2008.02893.x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18194422
Print-ISSN:
1538-7933
TUM Institution:
Frauenklinik und Poliklinik
 BibTeX