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Dokumenttyp:
journal article 
Autor(en):
Knör, S; Khrenov, A; Laufer, B; Benhida, A; Grailly, SC; Schwaab, R; Oldenburg, J; Beaufort, N; Magdolen, V; Saint-Remy, JM; Saenko, EL; Hauser, CA; Kessler, H 
Titel:
Efficient factor VIII affinity purification using a small synthetic ligand. 
Abstract:
BACKGROUND: Hemophilia A is currently treated by infusions of the coagulation factor (F) VIII, of which production and purification remain a challenging task. Current purification procedures using immunoaffinity chromatography are cumbersome, expensive, and suffer from the instability of the applied antibody ligands, which elute along with the product and contaminate it. Recently, FVIII was purified using octapeptide ligands, but their use is limited due to the low resistance to proteases. OBJEC...    »
 
Zeitschriftentitel:
J Thromb Haemost 
Jahr:
2008 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
470-7 
Sprache:
eng 
Print-ISSN:
1538-7933 
TUM Einrichtung:
Frauenklinik und Poliklinik