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Dokumenttyp:
journal article 
Autor(en):
Beaufort, N; Wojciechowski, P; Sommerhoff, CP; Szmyd, G; Dubin, G; Eick, S; Kellermann, J; Schmitt, M; Potempa, J; Magdolen, V 
Titel:
The human fibrinolytic system is a target for the staphylococcal metalloprotease aureolysin. 
Abstract:
The major opportunistic pathogen Staphylococcus aureus utilizes the human fibrinolytic system for invasion and spread via plasmin(ogen) binding and non-proteolytic activation. Because S. aureus secretes several proteases recently proposed as virulence factors, we explored whether these enzymes could add to the activation of the host's fibrinolytic system. Exposure of human pro-urokinase [pro-uPA (where uPA is urokinase-type plasminogen activator)] to conditioned growth media from staphylococcal...    »
 
Zeitschriftentitel:
Biochem J 
Jahr:
2008 
Band / Volume:
410 
Heft / Issue:
Seitenangaben Beitrag:
157-65 
Sprache:
eng 
Print-ISSN:
0264-6021 
TUM Einrichtung:
Frauenklinik und Poliklinik