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Document type:
journal article 
Author(s):
Beaufort, N; Wojciechowski, P; Sommerhoff, CP; Szmyd, G; Dubin, G; Eick, S; Kellermann, J; Schmitt, M; Potempa, J; Magdolen, V 
Title:
The human fibrinolytic system is a target for the staphylococcal metalloprotease aureolysin. 
Abstract:
The major opportunistic pathogen Staphylococcus aureus utilizes the human fibrinolytic system for invasion and spread via plasmin(ogen) binding and non-proteolytic activation. Because S. aureus secretes several proteases recently proposed as virulence factors, we explored whether these enzymes could add to the activation of the host's fibrinolytic system. Exposure of human pro-urokinase [pro-uPA (where uPA is urokinase-type plasminogen activator)] to conditioned growth media from staphylococcal...    »
 
Journal title abbreviation:
Biochem J 
Year:
2008 
Journal volume:
410 
Journal issue:
Pages contribution:
157-65 
Language:
eng 
Print-ISSN:
0264-6021 
TUM Institution:
Frauenklinik und Poliklinik