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Document type:
journal article 
Author(s):
Buters, JT; Kasche, A; Weichenmeier, I; Schober, W; Klaus, S; Traidl-Hoffmann, C; Menzel, A; Huss-Marp, J; Kramer, U; Behrendt, H 
Title:
Year-to-year variation in release of Bet v 1 allergen from birch pollen: evidence for geographical differences between West and South Germany. 
Abstract:
BACKGROUND: The release of the aeroallergen Bet v 1 from pollen is a major determinant in the etiology of allergic airway disease due to birch pollen. OBJECTIVE: We determined the release of the major birch pollen allergen Bet v 1 from pollen of birch trees growing in 2 different geographic regions in Germany for 2 consecutive years. METHODS: Catkins were collected during pollination in 2002 and 2003 from 82 healthy trees in South (Munich) and West Germany (North Rhine-Westphalia). The release of Bet v 1 from pollen samples was determined by a Bet v 1-specific ELISA. RESULTS: Pollen from South Germany released about 3 times more Bet v 1 than those from West Germany in both 2002 and 2003 (p = 0.034 and p = 0.007, respectively). This was independent of the number of pollen during the pollen flight season. In 2003, the release of Bet v 1 from pollen was more than 5 times higher than in 2002 in both regions (South Germany 6.1 times, p< 0.001; West Germany 5.4 times, p = 0.003). CONCLUSIONS: Despite large individual differences, there seem to be regional and year-to-year variations in Bet v 1 release from birch pollen. Therefore, the combination of pollen count and release of Bet v 1 from this pollen must be assessed to estimate Bet v 1 exposure reliably. 
Journal title abbreviation:
Int Arch Allergy Immunol 
Year:
2008 
Journal volume:
145 
Journal issue:
Pages contribution:
122-30 
Language:
eng 
Print-ISSN:
1018-2438 
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie ; Institut für Molekulare Allergologie und Umweltforschung