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Document type:
journal article 
Author(s):
Eckert, S; Eyer, P; Herkert, N; Bumm, R; Weber, G; Thiermann, H; Worek, F 
Title:
Comparison of the oxime-induced reactivation of erythrocyte and muscle acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity. 
Abstract:
The purpose of these experiments was to compare oxime-induced reactivation rate constants of acetylcholinesterase from different human tissue sources inhibited by organophosphorus compounds. To this end, preliminary testing was necessary to generate a stable system both for working with erythrocytes and musculature. We established a dynamically working in vitro model with a fixed enzyme source in a bioreactor that was perfused with acetylthiocholine, Ellman's reagent and any agent of interest (e...    »
 
Journal title abbreviation:
Biochem Pharmacol 
Year:
2008 
Journal volume:
75 
Journal issue:
Pages contribution:
698-703 
Language:
eng 
Print-ISSN:
0006-2952 
TUM Institution:
Chirurgiesche Klinik und Poliklinik