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Document type:
journal article 
Author(s):
De Filippo, K; Henderson, RB; Laschinger, M; Hogg, N 
Title:
Neutrophil chemokines KC and macrophage-inflammatory protein-2 are newly synthesized by tissue macrophages using distinct TLR signaling pathways. 
Abstract:
Neutrophils are the first immune cells to migrate into infected tissue sites. Therefore an important step in the initiation of an immune response is the synthesis of the neutrophil-recruiting chemokines. In this in vivo study in mice, we show that resident tissue macrophages are the source of the major neutrophil chemoattractants, KC and MIP-2. Synthesis of these chemokines is rapidly regulated at the transcriptional level by signaling through TLR2, TLR3, and TLR4 that have diverse specificities...    »
 
Journal title abbreviation:
J Immunol 
Year:
2008 
Journal volume:
180 
Journal issue:
Pages contribution:
4308-15 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
Chirurgiesche Klinik und Poliklinik