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Document type:
journal article 
Author(s):
Fre, S; Vignjevic, D; Schoumacher, M; Duffy, SL; Janssen, KP; Robine, S; Louvard, D 
Title:
Epithelial morphogenesis and intestinal cancer: new insights in signaling mechanisms. 
Abstract:
In this review, the major signal transduction pathways that have been shown to play an important role in intestinal homeostasis are highlighted. Each of them, the Wnt, Notch, Hedgehog, and Bone Morphogenetic Protein, as well as growth-factor regulated Receptor Tyrosine Kinases are depicted with a special emphasis through their involvement in stem cell maintenance and their role in intestinal tumorigenesis. Finally, we discuss recent data on the final steps of tumor progression, notably the forma...    »
 
Journal title abbreviation:
Adv Cancer Res 
Year:
2008 
Journal volume:
100 
Pages contribution:
85-111 
Language:
eng 
Print-ISSN:
0065-230X 
TUM Institution:
Chirurgiesche Klinik und Poliklinik