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Document type:
journal article 
Author(s):
Sakorafas, GH; Friess, H; Peros, G 
Title:
The genetic basis of hereditary medullary thyroid cancer: clinical implications for the surgeon, with a particular emphasis on the role of prophylactic thyroidectomy. 
Abstract:
Medullary thyroid cancer (MTC) may occur either sporadically or on a hereditary basis. Hereditary MTC may be observed with either multiple endocrine neoplasia syndromes (MEN 2A and MEN 2B) or as familial MTC (FMTC). Despite the rarity of these syndromes, early diagnosis is especially important, since MTC is a lethal disease if not promptly and appropriately treated. Recently, the development of genetic testing and direct DNA analysis allows the identification of asymptomatic patients. Surgical p...    »
 
Journal title abbreviation:
Endocr Relat Cancer 
Year:
2008 
Journal volume:
15 
Journal issue:
Pages contribution:
871-84 
Language:
eng 
Print-ISSN:
1351-0088 
TUM Institution:
Chirurgiesche Klinik und Poliklinik