Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Schmitz, F; Heit, A; Dreher, S; Eisenächer, K; Mages, J; Haas, T; Krug, A; Janssen, KP; Kirschning, CJ; Wagner, H 
Titel:
Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells. 
Abstract:
The mammalian target of rapamycin (mTOR) can be viewed as cellular master complex scoring cellular vitality and stress. Whether mTOR controls also innate immune-defenses is currently unknown. Here we demonstrate that TLR activate mTOR via phosphoinositide 3-kinase/Akt. mTOR physically associates with the MyD88 scaffold protein to allow activation of interferon regulatory factor-5 and interferon regulatory factor-7, known as master transcription factors for pro-inflammatory cytokine- and type I I...    »
 
Zeitschriftentitel:
Eur J Immunol 
Jahr:
2008 
Band / Volume:
38 
Heft / Issue:
11 
Seitenangaben Beitrag:
2981-92 
Sprache:
eng 
Print-ISSN:
0014-2980 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene; Chirurgiesche Klinik und Poliklinik