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Document type:
journal article 
Author(s):
Schmitz, F; Heit, A; Dreher, S; Eisenächer, K; Mages, J; Haas, T; Krug, A; Janssen, KP; Kirschning, CJ; Wagner, H 
Title:
Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells. 
Abstract:
The mammalian target of rapamycin (mTOR) can be viewed as cellular master complex scoring cellular vitality and stress. Whether mTOR controls also innate immune-defenses is currently unknown. Here we demonstrate that TLR activate mTOR via phosphoinositide 3-kinase/Akt. mTOR physically associates with the MyD88 scaffold protein to allow activation of interferon regulatory factor-5 and interferon regulatory factor-7, known as master transcription factors for pro-inflammatory cytokine- and type I I...    »
 
Journal title abbreviation:
Eur J Immunol 
Year:
2008 
Journal volume:
38 
Journal issue:
11 
Pages contribution:
2981-92 
Language:
eng 
Print-ISSN:
0014-2980 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene ; Chirurgiesche Klinik und Poliklinik