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Document type:
journal article 
Author(s):
Geisler, F; Nagl, F; Mazur, PK; Lee, M; Zimber-Strobl, U; Strobl, LJ; Radtke, F; Schmid, RM; Siveke, JT 
Title:
Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice. 
Abstract:
The Notch pathway is an evolutionary conserved, intercellular signaling pathway that plays an important role in cell fate specification and the embryonic development of many organs, including the liver. In humans, mutations in the Notch receptor ligand Jagged1 gene result in defective intrahepatic bile duct (IHBD) development in Alagille syndrome. Developmental abnormalities of IHBD in mice doubly heterozygous for Jagged1 and Notch2 mutations propose that interactions of Jagged1 and its receptor...    »
 
Journal title abbreviation:
Hepatology 
Year:
2008 
Journal volume:
48 
Journal issue:
Pages contribution:
607-16 
Language:
eng 
Print-ISSN:
0270-9139 
TUM Institution:
II. Medizinische Klinik und Poliklinik