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Dokumenttyp:
journal article 
Autor(en):
Geisler, F; Nagl, F; Mazur, PK; Lee, M; Zimber-Strobl, U; Strobl, LJ; Radtke, F; Schmid, RM; Siveke, JT 
Titel:
Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice. 
Abstract:
The Notch pathway is an evolutionary conserved, intercellular signaling pathway that plays an important role in cell fate specification and the embryonic development of many organs, including the liver. In humans, mutations in the Notch receptor ligand Jagged1 gene result in defective intrahepatic bile duct (IHBD) development in Alagille syndrome. Developmental abnormalities of IHBD in mice doubly heterozygous for Jagged1 and Notch2 mutations propose that interactions of Jagged1 and its receptor...    »
 
Zeitschriftentitel:
Hepatology 
Jahr:
2008 
Band / Volume:
48 
Heft / Issue:
Seitenangaben Beitrag:
607-16 
Sprache:
eng 
Print-ISSN:
0270-9139 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik