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Dokumenttyp:
journal article 
Autor(en):
Vallabhapurapu, S; Powolny-Budnicka, I; Riemann, M; Schmid, RM; Paxian, S; Pfeffer, K; Körner, H; Weih, F 
Titel:
Rel/NF-kappaB family member RelA regulates NK1.1- to NK1.1+ transition as well as IL-15-induced expansion of NKT cells. 
Abstract:
Development of NKT cells was shown to depend on lymphotoxin (LT) and IL-15 signaling pathways as well as on cytokine receptor common gamma chain. After positive selection, NKT-cell precursors transit through progressive maturation stages including proliferative expansion within the NK1.1(-) window. The transcription factors that integrate different signaling pathways into different stages of NKT-cell development are not well characterized. Here, we show that the Rel/NF-kappaB family member RelA...    »
 
Zeitschriftentitel:
Eur J Immunol 
Jahr:
2008 
Band / Volume:
38 
Heft / Issue:
12 
Seitenangaben Beitrag:
3508-19 
Sprache:
eng 
Print-ISSN:
0014-2980 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik