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Dokumenttyp:
journal article 
Autor(en):
Antoniou, AC; Spurdle, AB; Sinilnikova, OM; Healey, S; Pooley, KA; Schmutzler, RK; Versmold, B; Engel, C; Meindl, A; Arnold, N; Hofmann, W; Sutter, C; Niederacher, D; Deissler, H; Caldes, T; Kämpjärvi, K; Nevanlinna, H; Simard, J; Beesley, J; Chen, X; Kathleen Cuningham Consortium for Research into Familial Breast Cancer; Neuhausen, SL; Rebbeck, TR; Wagner, T; Lynch, HT; Isaacs, C; Weitzel, J; Ganz, PA; Daly, MB; Tomlinson, G; Olopade, OI; Blum, JL; Couch, FJ; Peterlongo, P; Manoukian, S; Barile...    »
 
Titel:
Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. 
Abstract:
Germline mutations in BRCA1 and BRCA2 confer high risks of breast cancer. However, evidence suggests that these risks are modified by other genetic or environmental factors that cluster in families. A recent genome-wide association study has shown that common alleles at single nucleotide polymorphisms (SNPs) in FGFR2 (rs2981582), TNRC9 (rs3803662), and MAP3K1 (rs889312) are associated with increased breast cancer risks in the general population. To investigate whether these loci are also associa...    »
 
Zeitschriftentitel:
Am J Hum Genet 
Jahr:
2008 
Band / Volume:
82 
Heft / Issue:
Seitenangaben Beitrag:
937-48 
Sprache:
eng 
Print-ISSN:
0002-9297 
TUM Einrichtung:
Frauenklinik und Poliklinik