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Document type:
journal article 
Author(s):
Nieder, C; Astner, ST; Andratschke, NH; Adam, M 
Title:
Disease presentation and outcome in very young patients with brain metastases from breast cancer. 
Abstract:
AIMS AND BACKGROUND: Little information is available on disease presentation and treatment outcome in very young patients with brain metastases from breast cancer. Therefore, we evaluated our results in this group. METHODS: In our database, 7/74 breast cancer patients treated for brain metastases were< 40 years old. All received whole-brain radiation therapy plus individual local or systemic measures. RESULTS: In patients with information available, tumors were poorly differentiated and metastatic to the axillary lymph nodes at primary diagnosis. All patients had extracranial metastases. Two died from their brain disease within 5 months. Five patients died from extracranial progression after 3-84 months (2 long-term survivors beyond 2 years, characterized by single brain lesions and high performance status). CONCLUSIONS: Very young patients did not achieve a better outcome than intermediate age groups. Whole-brain radiation therapy plus surgery or radiosurgery provided durable CNS control in most of the patients. Improved systemic therapy appears to represent the key to a better outcome. 
Journal title abbreviation:
Tumori 
Year:
2008 
Journal volume:
94 
Journal issue:
Pages contribution:
691-3 
Language:
eng 
Print-ISSN:
0300-8916 
TUM Institution:
r Strahlentherapie und Radiologische Onkologie