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Document type:
journal article 
Author(s):
Schaefer, KL; Eisenacher, M; Braun, Y; Brachwitz, K; Wai, DH; Dirksen, U; Lanvers-Kaminsky, C; Juergens, H; Herrero, D; Stegmaier, S; Koscielniak, E; Eggert, A; Nathrath, M; Gosheger, G; Schneider, DT; Bury, C; Diallo-Danebrock, R; Ottaviano, L; Gabbert, HE; Poremba, C 
Title:
Microarray analysis of Ewing's sarcoma family of tumours reveals characteristic gene expression signatures associated with metastasis and resistance to chemotherapy. 
Abstract:
In Ewing's sarcoma family of tumours (ESFT), the clinically most adverse prognostic parameters are the presence of tumour metastasis at time of diagnosis and poor response to neoadjuvant chemotherapy. To identify genes differentially regulated between metastatic and localised tumours, we analysed 27 ESFT specimens using Affymetrix microarrays. Functional annotation of differentially regulated genes revealed 29 over-represented pathways including PDGF, TP53, NOTCH, and WNT1-signalling. Regression...    »
 
Journal title abbreviation:
Eur J Cancer 
Year:
2008 
Journal volume:
44 
Journal issue:
Pages contribution:
699-709 
Language:
eng 
Print-ISSN:
0959-8049 
TUM Institution:
Kinderklinik und Poliklinik