Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Schaefer, KL; Eisenacher, M; Braun, Y; Brachwitz, K; Wai, DH; Dirksen, U; Lanvers-Kaminsky, C; Juergens, H; Herrero, D; Stegmaier, S; Koscielniak, E; Eggert, A; Nathrath, M; Gosheger, G; Schneider, DT; Bury, C; Diallo-Danebrock, R; Ottaviano, L; Gabbert, HE; Poremba, C 
Titel:
Microarray analysis of Ewing's sarcoma family of tumours reveals characteristic gene expression signatures associated with metastasis and resistance to chemotherapy. 
Abstract:
In Ewing's sarcoma family of tumours (ESFT), the clinically most adverse prognostic parameters are the presence of tumour metastasis at time of diagnosis and poor response to neoadjuvant chemotherapy. To identify genes differentially regulated between metastatic and localised tumours, we analysed 27 ESFT specimens using Affymetrix microarrays. Functional annotation of differentially regulated genes revealed 29 over-represented pathways including PDGF, TP53, NOTCH, and WNT1-signalling. Regression...    »
 
Zeitschriftentitel:
Eur J Cancer 
Jahr:
2008 
Band / Volume:
44 
Heft / Issue:
Seitenangaben Beitrag:
699-709 
Sprache:
eng 
Print-ISSN:
0959-8049 
TUM Einrichtung:
Kinderklinik und Poliklinik