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Document type:
journal article 
Author(s):
Novak, N; Baurecht, H; Schäfer, T; Rodriguez, E; Wagenpfeil, S; Klopp, N; Heinrich, J; Behrendt, H; Ring, J; Wichmann, E; Illig, T; Weidinger, S 
Title:
Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel. 
Abstract:
Allergic contact dermatitis is one of the most frequent dermatological problems affecting 7% of the general population. Impaired skin barrier function facilitates the penetration of contact allergens and irritants into the epidermal layer and is regarded as an important cofactor promoting the process of allergic contact sensitization. Filaggrin is crucial for the maintenance of the skin barrier function. Loss-of-function mutations within the filaggrin (FLG) gene are associated with skin barrier...    »
 
Journal title abbreviation:
J Invest Dermatol 
Year:
2008 
Journal volume:
128 
Journal issue:
Pages contribution:
1430-5 
Language:
eng 
Print-ISSN:
0022-202X 
TUM Institution:
r Medizinische Statistik und Epidemiologie; r Dermatologie und Allergologie