Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Novak, N; Baurecht, H; Schäfer, T; Rodriguez, E; Wagenpfeil, S; Klopp, N; Heinrich, J; Behrendt, H; Ring, J; Wichmann, E; Illig, T; Weidinger, S 
Titel:
Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel. 
Abstract:
Allergic contact dermatitis is one of the most frequent dermatological problems affecting 7% of the general population. Impaired skin barrier function facilitates the penetration of contact allergens and irritants into the epidermal layer and is regarded as an important cofactor promoting the process of allergic contact sensitization. Filaggrin is crucial for the maintenance of the skin barrier function. Loss-of-function mutations within the filaggrin (FLG) gene are associated with skin barrier...    »
 
Zeitschriftentitel:
J Invest Dermatol 
Jahr:
2008 
Band / Volume:
128 
Heft / Issue:
Seitenangaben Beitrag:
1430-5 
Sprache:
eng 
Print-ISSN:
0022-202X 
TUM Einrichtung:
r Medizinische Statistik und Epidemiologie; r Dermatologie und Allergologie