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Dokumenttyp:
journal article 
Autor(en):
Mamani-Matsuda, M; Cosma, A; Weller, S; Faili, A; Staib, C; Garçon, L; Hermine, O; Beyne-Rauzy, O; Fieschi, C; Pers, JO; Arakelyan, N; Varet, B; Sauvanet, A; Berger, A; Paye, F; Andrieu, JM; Michel, M; Godeau, B; Buffet, P; Reynaud, CA; Weill, JC 
Titel:
The human spleen is a major reservoir for long-lived vaccinia virus-specific memory B cells. 
Abstract:
The fact that you can vaccinate a child at 5 years of age and find lymphoid B cells and antibodies specific for this vaccination 70 years later remains an immunologic enigma. It has never been determined how these long-lived memory B cells are maintained and whether they are protected by storage in a special niche. We report that, whereas blood and spleen compartments present similar frequencies of IgG(+) cells, antismallpox memory B cells are specifically enriched in the spleen where they accou...    »
 
Zeitschriftentitel:
Blood 
Jahr:
2008 
Band / Volume:
111 
Heft / Issue:
Seitenangaben Beitrag:
4653-9 
Sprache:
eng 
Print-ISSN:
0006-4971 
TUM Einrichtung:
r Virologie