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journal article 
Kutscher, S; Dembek, CJ; Allgayer, S; Heltai, S; Stadlbauer, B; Biswas, P; Nozza, S; Tambussi, G; Bogner, JR; Stellbrink, HJ; Goebel, FD; Lusso, P; Tinelli, M; Poli, G; Erfle, V; Pohla, H; Malnati, M; Cosma, A 
The intracellular detection of MIP-1beta enhances the capacity to detect IFN-gamma mediated HIV-1-specific CD8 T-cell responses in a flow cytometric setting providing a sensitive alternative to the ELISPOT. 
ABSTRACT: BACKGROUND: T-cell mediated immunity likely plays an important role in controlling HIV-1 infection and progression to AIDS. Several candidate vaccines against HIV-1 aim at stimulating cellular immune responses, either alone or together with the induction of neutralizing antibodies, and assays able to measure CD8 and CD4 T-cell responses need to be implemented. At present, the IFN-gamma-based ELISPOT assay is considered the gold standard and it is broadly preferred as primary assay for...    »
Journal title abbreviation:
AIDS Res Ther 
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TUM Institution:
Institut für Virologie