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Document type:
journal article 
Author(s):
Greil, CS; Vorberg, IM; Ward, AE; Meade-White, KD; Harris, DA; Priola, SA 
Title:
Acute cellular uptake of abnormal prion protein is cell type and scrapie-strain independent. 
Abstract:
Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases that include Creutzfeldt-Jakob disease, bovine spongiform encephalopathy and sheep scrapie. Although one of the earliest events during TSE infection is the cellular uptake of protease resistant prion protein (PrP-res), this process is poorly understood due to the difficulty of clearly distinguishing input PrP-res from either PrP-res or protease-sensitive PrP (PrP-sen) made by the cell. Using PrP-res tagged with...    »
 
Journal title abbreviation:
Virology 
Year:
2008 
Journal volume:
379 
Journal issue:
Pages contribution:
284-93 
Language:
eng 
Print-ISSN:
0042-6822 
TUM Institution:
Institut für Virologie