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Document type:
journal article 
Author(s):
Caetano, FA; Lopes, MH; Hajj, GN; Machado, CF; Pinto Arantes, C; Magalhães, AC; Vieira, Mde P; Américo, TA; Massensini, AR; Priola, SA; Vorberg, I; Gomez, MV; Linden, R; Prado, VF; Martins, VR; Prado, MA 
Title:
Endocytosis of prion protein is required for ERK1/2 signaling induced by stress-inducible protein 1. 
Abstract:
The secreted cochaperone STI1 triggers activation of protein kinase A (PKA) and ERK1/2 signaling by interacting with the cellular prion (PrP(C)) at the cell surface, resulting in neuroprotection and increased neuritogenesis. Here, we investigated whether STI1 triggers PrP(C) trafficking and tested whether this process controls PrP(C)-dependent signaling. We found that STI1, but not a STI1 mutant unable to bind PrP(C), induced PrP(C) endocytosis. STI1-induced signaling did not occur in cells devo...    »
 
Journal title abbreviation:
J Neurosci 
Year:
2008 
Journal volume:
28 
Journal issue:
26 
Pages contribution:
6691-702 
Language:
eng 
Print-ISSN:
0270-6474 
TUM Institution:
Institut für Virologie