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Document type:
journal article 
Author(s):
Chen, JW; Breckwoldt, MO; Aikawa, E; Chiang, G; Weissleder, R 
Title:
Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis. 
Abstract:
Inflammatory demyelinating plaques are the pathologic hallmark of active multiple sclerosis and often precede clinical manifestations. Non-invasive early detection of active plaques would thus be crucial in establishing pre-symptomatic diagnosis and could lead to early preventive treatment strategies. Using murine experimental autoimmune encephalomyelitis as a model of multiple sclerosis, we demonstrate that a prototype paramagnetic myeloperoxidase (MPO) sensor can detect and confirm more, small...    »
 
Journal title abbreviation:
Brain 
Year:
2008 
Journal volume:
131 
Journal issue:
Pt 4 
Pages contribution:
1123-33 
Language:
eng 
Print-ISSN:
0006-8950 
TUM Institution:
r Neuroradiologie