User: Guest  Login
Document type:
journal article 
Author(s):
Boltze, J; Förschler, A; Nitzsche, B; Waldmin, D; Hoffmann, A; Boltze, CM; Dreyer, AY; Goldammer, A; Reischauer, A; Härtig, W; Geiger, KD; Barthel, H; Emmrich, F; Gille, U 
Title:
Permanent middle cerebral artery occlusion in sheep: a novel large animal model of focal cerebral ischemia. 
Abstract:
As effective stroke treatment by thrombolysis is bound to a narrow time window excluding most patients, numerous experimental treatment strategies have been developed to gain new options for stroke treatment. However, all approaches using neuroprotective agents that have been successfully evaluated in rodents have subsequently failed in clinical trials. Existing large animal models are of significant scientific value, but sometimes limited by ethical drawbacks and mostly do not allow for long-te...    »
 
Journal title abbreviation:
J Cereb Blood Flow Metab 
Year:
2008 
Journal volume:
28 
Journal issue:
12 
Pages contribution:
1951-64 
Language:
eng 
Print-ISSN:
0271-678X 
TUM Institution:
Abteilung für Neuroradiologie