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Dokumenttyp:
journal article 
Autor(en):
Engel, JB; Honig, A; Schönhals, T; Weidler, C; Häusler, S; Krockenberger, M; Grunewald, TG; Dombrowski, Y; Rieger, L; Dietl, J; Wischhusen, J 
Titel:
Perifosine inhibits growth of human experimental endometrial cancers by blockade of AKT phosphorylation. 
Abstract:
OBJECTIVE: Perifosine is an orally active alkylphospholipid analog, which has shown anti-tumor activity in a variety of cancers by inhibition of AKT phosphorylation. The objective of the current study was to evaluate its efficacy in in vitro models of human endometrial cancer. STUDY DESIGN: The effect of 10microM and 40microM perifosine on AKT phophorylation in human endometrial cancer cell lines Ishikawa and HEC 1A was determined by Western blotting. To screen for a putative anti-tumor effect,...    »
 
Zeitschriftentitel:
Eur J Obstet Gynecol Reprod Biol 
Jahr:
2008 
Band / Volume:
141 
Heft / Issue:
Seitenangaben Beitrag:
64-9 
Sprache:
eng 
Print-ISSN:
0301-2115 
TUM Einrichtung:
Kinderklinik und Poliklinik