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Document type:
journal article 
Author(s):
Eckmann, L; Nebelsiek, T; Fingerle, AA; Dann, SM; Mages, J; Lang, R; Robine, S; Kagnoff, MF; Schmid, RM; Karin, M; Arkan, MC; Greten, FR 
Title:
Opposing functions of IKKbeta during acute and chronic intestinal inflammation. 
Abstract:
NF-kappaB is a key transcriptional regulator of inflammatory responses, but also controls expression of prosurvival genes, whose products protect tissues from damage and may thus act indirectly in an antiinflammatory fashion. The variable importance of these two distinct NF-kappaB-controlled responses impacts the potential utility of NF-kappaB inhibition as a treatment strategy for intractable inflammatory conditions, such as inflammatory bowel disease. Here, we show in murine models that inhibi...    »
 
Journal title abbreviation:
Proc Natl Acad Sci U S A 
Year:
2008 
Journal volume:
105 
Journal issue:
39 
Pages contribution:
15058-63 
Language:
eng 
Print-ISSN:
0027-8424 
TUM Institution:
Institut für Radiologie ; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene ; II. Medizinische Klinik und Poliklinik ; III. Medizinische Klinik und Poliklinik