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Dokumenttyp:
journal article 
Autor(en):
Eckmann, L; Nebelsiek, T; Fingerle, AA; Dann, SM; Mages, J; Lang, R; Robine, S; Kagnoff, MF; Schmid, RM; Karin, M; Arkan, MC; Greten, FR 
Titel:
Opposing functions of IKKbeta during acute and chronic intestinal inflammation. 
Abstract:
NF-kappaB is a key transcriptional regulator of inflammatory responses, but also controls expression of prosurvival genes, whose products protect tissues from damage and may thus act indirectly in an antiinflammatory fashion. The variable importance of these two distinct NF-kappaB-controlled responses impacts the potential utility of NF-kappaB inhibition as a treatment strategy for intractable inflammatory conditions, such as inflammatory bowel disease. Here, we show in murine models that inhibi...    »
 
Zeitschriftentitel:
Proc Natl Acad Sci U S A 
Jahr:
2008 
Band / Volume:
105 
Heft / Issue:
39 
Seitenangaben Beitrag:
15058-63 
Sprache:
eng 
Print-ISSN:
0027-8424 
TUM Einrichtung:
r Radiologie; r Medizinische Mikrobiologie, Immunologie und Hygiene; II. Medizinische Klinik und Poliklinik