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Document type:
journal article 
Author(s):
Carlson, TR; Hu, H; Braren, R; Kim, YH; Wang, RA 
Title:
Cell-autonomous requirement for beta1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice. 
Abstract:
beta1 integrin (encoded by Itgb1) is established as a regulator of angiogenesis based upon the phenotypes of complete knockouts of beta1 heterodimer partners or ligands and upon antibody inhibition studies in mice. Its direct function in endothelial cells (ECs) in vivo has not been determined because Itgb1(-/-) embryos die before vascular development. Excision of Itgb1 from ECs and a subset of hematopoietic cells, using Tie2-Cre, resulted in abnormal vascular development by embryonic day (e) 8.5...    »
 
Journal title abbreviation:
Development 
Year:
2008 
Journal volume:
135 
Journal issue:
12 
Pages contribution:
2193-202 
Language:
eng 
Print-ISSN:
0950-1991 
TUM Institution:
Institut für Radiologie