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Dokumenttyp:
journal article 
Autor(en):
Carlson, TR; Hu, H; Braren, R; Kim, YH; Wang, RA 
Titel:
Cell-autonomous requirement for beta1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice. 
Abstract:
beta1 integrin (encoded by Itgb1) is established as a regulator of angiogenesis based upon the phenotypes of complete knockouts of beta1 heterodimer partners or ligands and upon antibody inhibition studies in mice. Its direct function in endothelial cells (ECs) in vivo has not been determined because Itgb1(-/-) embryos die before vascular development. Excision of Itgb1 from ECs and a subset of hematopoietic cells, using Tie2-Cre, resulted in abnormal vascular development by embryonic day (e) 8.5...    »
 
Zeitschriftentitel:
Development 
Jahr:
2008 
Band / Volume:
135 
Heft / Issue:
12 
Seitenangaben Beitrag:
2193-202 
Sprache:
eng 
Print-ISSN:
0950-1991 
TUM Einrichtung:
r Radiologie