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Dokumenttyp:
journal article 
Autor(en):
Föller, M; Feil, S; Ghoreschi, K; Koka, S; Gerling, A; Thunemann, M; Hofmann, F; Schuler, B; Vogel, J; Pichler, B; Kasinathan, RS; Nicolay, JP; Huber, SM; Lang, F; Feil, R 
Titel:
Anemia and splenomegaly in cGKI-deficient mice. 
Abstract:
To explore the functional significance of cGMP-dependent protein kinase type I (cGKI) in the regulation of erythrocyte survival, gene-targeted mice lacking cGKI were compared with their control littermates. By the age of 10 weeks, cGKI-deficient mice exhibited pronounced anemia and splenomegaly. Compared with control mice, the cGKI mutants had significantly lower red blood cell count, packed cell volume, and hemoglobin concentration. Anemia was associated with a higher reticulocyte number and an...    »
 
Zeitschriftentitel:
Proc Natl Acad Sci U S A 
Jahr:
2008 
Band / Volume:
105 
Heft / Issue:
18 
Seitenangaben Beitrag:
6771-6 
Sprache:
eng 
Print-ISSN:
0027-8424 
TUM Einrichtung:
r Pharmakologie und Toxikologie