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Document type:
journal article 
Author(s):
Thum, T; Gross, C; Fiedler, J; Fischer, T; Kissler, S; Bussen, M; Galuppo, P; Just, S; Rottbauer, W; Frantz, S; Castoldi, M; Soutschek, J; Koteliansky, V; Rosenwald, A; Basson, MA; Licht, JD; Pena, JT; Rouhanifard, SH; Muckenthaler, MU; Tuschl, T; Martin, GR; Bauersachs, J; Engelhardt, S 
Title:
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. 
Abstract:
MicroRNAs comprise a broad class of small non-coding RNAs that control expression of complementary target messenger RNAs. Dysregulation of microRNAs by several mechanisms has been described in various disease states including cardiac disease. Whereas previous studies of cardiac disease have focused on microRNAs that are primarily expressed in cardiomyocytes, the role of microRNAs expressed in other cell types of the heart is unclear. Here we show that microRNA-21 (miR-21, also known as Mirn21) r...    »
 
Journal title abbreviation:
Nature 
Year:
2008 
Journal volume:
456 
Journal issue:
7224 
Pages contribution:
980-4 
Language:
eng 
Print-ISSN:
0028-0836 
TUM Institution:
r Pharmakologie und Toxikologie