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Dokumenttyp:
journal article 
Autor(en):
Thum, T; Gross, C; Fiedler, J; Fischer, T; Kissler, S; Bussen, M; Galuppo, P; Just, S; Rottbauer, W; Frantz, S; Castoldi, M; Soutschek, J; Koteliansky, V; Rosenwald, A; Basson, MA; Licht, JD; Pena, JT; Rouhanifard, SH; Muckenthaler, MU; Tuschl, T; Martin, GR; Bauersachs, J; Engelhardt, S 
Titel:
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. 
Abstract:
MicroRNAs comprise a broad class of small non-coding RNAs that control expression of complementary target messenger RNAs. Dysregulation of microRNAs by several mechanisms has been described in various disease states including cardiac disease. Whereas previous studies of cardiac disease have focused on microRNAs that are primarily expressed in cardiomyocytes, the role of microRNAs expressed in other cell types of the heart is unclear. Here we show that microRNA-21 (miR-21, also known as Mirn21) r...    »
 
Zeitschriftentitel:
Nature 
Jahr:
2008 
Band / Volume:
456 
Heft / Issue:
7224 
Seitenangaben Beitrag:
980-4 
Sprache:
eng 
Print-ISSN:
0028-0836 
TUM Einrichtung:
r Pharmakologie und Toxikologie