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Dokumenttyp:
journal article 
Autor(en):
Hoesl, E; Stieber, J; Herrmann, S; Feil, S; Tybl, E; Hofmann, F; Feil, R; Ludwig, A 
Titel:
Tamoxifen-inducible gene deletion in the cardiac conduction system. 
Abstract:
Temporally controlled gene deletion provides a powerful technique for examination of gene function in vivo. To permit use of this technology in the study of cardiac pacemaking, we attempted to generate a mouse line expressing an inducible Cre recombinase selectively in cardiac pacemaker cells. The tamoxifen-inducible CreER(T2) construct was'knocked in' into the pacemaker channel HCN4 locus. In the absence of inducing agent, recombination was undetectable in HCN4-KiT mice. After injection of tamo...    »
 
Zeitschriftentitel:
J Mol Cell Cardiol 
Jahr:
2008 
Band / Volume:
45 
Heft / Issue:
Seitenangaben Beitrag:
62-9 
Sprache:
eng 
Print-ISSN:
0022-2828 
TUM Einrichtung:
r Pharmakologie und Toxikologie