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Dokumenttyp:
journal article 
Autor(en):
Kawasaki, Y; Kugimiya, F; Chikuda, H; Kamekura, S; Ikeda, T; Kawamura, N; Saito, T; Shinoda, Y; Higashikawa, A; Yano, F; Ogasawara, T; Ogata, N; Hoshi, K; Hofmann, F; Woodgett, JR; Nakamura, K; Chung, UI; Kawaguchi, H 
Titel:
Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes. 
Abstract:
cGMP-dependent protein kinase II (cGKII; encoded by PRKG2) is a serine/threonine kinase that is critical for skeletal growth in mammals; in mice, cGKII deficiency results in dwarfism. Using radiographic analysis, we determined that this growth defect was a consequence of an elongated growth plate and impaired chondrocyte hypertrophy. To investigate the mechanism of cGKII-mediated chondrocyte hypertrophy, we performed a kinase substrate array and identified glycogen synthase kinase-3beta (GSK-3...    »
 
Zeitschriftentitel:
J Clin Invest 
Jahr:
2008 
Band / Volume:
118 
Heft / Issue:
Seitenangaben Beitrag:
2506-15 
Sprache:
eng 
Print-ISSN:
0021-9738 
TUM Einrichtung:
r Pharmakologie und Toxikologie