Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Busche, MA; Eichhoff, G; Adelsberger, H; Abramowski, D; Wiederhold, KH; Haass, C; Staufenbiel, M; Konnerth, A; Garaschuk, O 
Titel:
Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease. 
Abstract:
The neurodegeneration observed in Alzheimer's disease has been associated with synaptic dismantling and progressive decrease in neuronal activity. We tested this hypothesis in vivo by using two-photon Ca2+ imaging in a mouse model of Alzheimer's disease. Although a decrease in neuronal activity was seen in 29% of layer 2/3 cortical neurons, 21% of neurons displayed an unexpected increase in the frequency of spontaneous Ca2+ transients. These "hyperactive" neurons were found exclusively near the...    »
 
Zeitschriftentitel:
Science 
Jahr:
2008 
Band / Volume:
321 
Heft / Issue:
5896 
Seitenangaben Beitrag:
1686-9 
Sprache:
eng 
Print-ISSN:
0036-8075 
TUM Einrichtung:
r Neurowissenschaften