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Document type:
journal article 
Author(s):
Busche, MA; Eichhoff, G; Adelsberger, H; Abramowski, D; Wiederhold, KH; Haass, C; Staufenbiel, M; Konnerth, A; Garaschuk, O 
Title:
Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease. 
Abstract:
The neurodegeneration observed in Alzheimer's disease has been associated with synaptic dismantling and progressive decrease in neuronal activity. We tested this hypothesis in vivo by using two-photon Ca2+ imaging in a mouse model of Alzheimer's disease. Although a decrease in neuronal activity was seen in 29% of layer 2/3 cortical neurons, 21% of neurons displayed an unexpected increase in the frequency of spontaneous Ca2+ transients. These "hyperactive" neurons were found exclusively near the...    »
 
Journal title abbreviation:
Science 
Year:
2008 
Journal volume:
321 
Journal issue:
5896 
Pages contribution:
1686-9 
Language:
eng 
Print-ISSN:
0036-8075 
TUM Institution:
Institut für Neurowissenschaften