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Document type:
journal article 
Author(s):
Song, JW; Misgeld, T; Kang, H; Knecht, S; Lu, J; Cao, Y; Cotman, SL; Bishop, DL; Lichtman, JW 
Title:
Lysosomal activity associated with developmental axon pruning. 
Abstract:
Clearance of cellular debris is a critical feature of the developing nervous system, as evidenced by the severe neurological consequences of lysosomal storage diseases in children. An important developmental process, which generates considerable cellular debris, is synapse elimination, in which many axonal branches are pruned. The fate of these pruned branches is not known. Here, we investigate the role of lysosomal activity in neurons and glia in the removal of axon branches during early postna...    »
 
Journal title abbreviation:
J Neurosci 
Year:
2008 
Journal volume:
28 
Journal issue:
36 
Pages contribution:
8993-9001 
Language:
eng 
Print-ISSN:
0270-6474 
TUM Institution:
Institut für Neurowissenschaften