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Document type:
journal article 
Author(s):
Schmidt, F; Knobbe, CB; Frank, B; Wolburg, H; Weller, M 
Title:
The topoisomerase II inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines. 
Abstract:
The protein tyrosine kinase inhibitor, genistein, has been reported to inhibit proliferation and to induce cell death in various non-solid and solid cancer cell lines. Herein, we examined the effects of genistein in several human malignant glioma cell lines. We found that genistein inhibited the proliferation of LN-18, LNT-229, LN-308 and T98G cells at EC50 concentrations of 25-80 microM (72 h of exposure). The growth of a non-neoplastic immortalized human astrocyte cell line, SV-FHAS, was inhib...    »
 
Journal title abbreviation:
Oncol Rep 
Year:
2008 
Journal volume:
19 
Journal issue:
Pages contribution:
1061-6 
Language:
eng 
Print-ISSN:
1021-335X 
TUM Institution:
Neurologische Klinik und Poliklinik