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Dokumenttyp:
journal article 
Autor(en):
Schmidt, F; Knobbe, CB; Frank, B; Wolburg, H; Weller, M 
Titel:
The topoisomerase II inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines. 
Abstract:
The protein tyrosine kinase inhibitor, genistein, has been reported to inhibit proliferation and to induce cell death in various non-solid and solid cancer cell lines. Herein, we examined the effects of genistein in several human malignant glioma cell lines. We found that genistein inhibited the proliferation of LN-18, LNT-229, LN-308 and T98G cells at EC50 concentrations of 25-80 microM (72 h of exposure). The growth of a non-neoplastic immortalized human astrocyte cell line, SV-FHAS, was inhib...    »
 
Zeitschriftentitel:
Oncol Rep 
Jahr:
2008 
Band / Volume:
19 
Heft / Issue:
Seitenangaben Beitrag:
1061-6 
Sprache:
eng 
Print-ISSN:
1021-335X 
TUM Einrichtung:
Neurologische Klinik und Poliklinik