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Dokumenttyp:
journal article 
Autor(en):
Winkelmann, J 
Titel:
Genetics of restless legs syndrome. 
Abstract:
Restless legs syndrome (RLS) is a highly familial trait with heritability estimates of about 50%. It is a polygenetic disorder in which a number of variants contribute to the phenotype. Linkage studies in families with RLS revealed several loci but have not yet led to the identification of disease-causing sequence variants. Phenocopies, nonpenetrance, and possible intrafamilial heterogeneity make it difficult to define the exact candidate region. Genome-wide association studies identified varian...    »
 
Zeitschriftentitel:
Curr Neurol Neurosci Rep 
Jahr:
2008 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
211-6 
Sprache:
eng 
Print-ISSN:
1528-4042 
TUM Einrichtung:
Neurologische Klinik und Poliklinik