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Dokumenttyp:
journal article 
Autor(en):
Hoffmann, S; Cepok, S; Grummel, V; Lehmann-Horn, K; Hackermueller, J; Stadler, PF; Hartung, HP; Berthele, A; Deisenhammer, F; Wasmuth, R; Hemmer, B 
Titel:
HLA-DRB1*0401 and HLA-DRB1*0408 are strongly associated with the development of antibodies against interferon-beta therapy in multiple sclerosis. 
Abstract:
The formation of antibodies to interferon-beta (IFN-beta), a protein-based disease-modifying agent for multiple sclerosis (MS), is a problem in clinical practice. These antibodies may neutralize the biological effects of the protein drug, potentially decreasing its therapeutic effects. By high-resolution HLA class I and II typing we identified two HLA class II alleles associated with the development of antibodies to IFN-beta. In two independent continuous and binary-trait association studies, HL...    »
 
Zeitschriftentitel:
Am J Hum Genet 
Jahr:
2008 
Band / Volume:
83 
Heft / Issue:
Seitenangaben Beitrag:
219-27 
Sprache:
eng 
Print-ISSN:
0002-9297 
TUM Einrichtung:
Neurologische Klinik und Poliklinik