User: Guest  Login
Document type:
journal article 
Author(s):
Hoffmann, S; Cepok, S; Grummel, V; Lehmann-Horn, K; Hackermueller, J; Stadler, PF; Hartung, HP; Berthele, A; Deisenhammer, F; Wasmuth, R; Hemmer, B 
Title:
HLA-DRB1*0401 and HLA-DRB1*0408 are strongly associated with the development of antibodies against interferon-beta therapy in multiple sclerosis. 
Abstract:
The formation of antibodies to interferon-beta (IFN-beta), a protein-based disease-modifying agent for multiple sclerosis (MS), is a problem in clinical practice. These antibodies may neutralize the biological effects of the protein drug, potentially decreasing its therapeutic effects. By high-resolution HLA class I and II typing we identified two HLA class II alleles associated with the development of antibodies to IFN-beta. In two independent continuous and binary-trait association studies, HL...    »
 
Journal title abbreviation:
Am J Hum Genet 
Year:
2008 
Journal volume:
83 
Journal issue:
Pages contribution:
219-27 
Language:
eng 
Print-ISSN:
0002-9297 
TUM Institution:
Neurologische Klinik und Poliklinik