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Document type:
journal article 
Author(s):
Weidinger, S; Baurecht, H; Wagenpfeil, S; Henderson, J; Novak, N; Sandilands, A; Chen, H; Rodriguez, E; O'Regan, GM; Watson, R; Liao, H; Zhao, Y; Barker, JN; Allen, M; Reynolds, N; Meggitt, S; Northstone, K; Smith, GD; Strobl, C; Stahl, C; Kneib, T; Klopp, N; Bieber, T; Behrendt, H; Palmer, CN; Wichmann, HE; Ring, J; Illig, T; McLean, WH; Irvine, AD 
Title:
Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk. 
Abstract:
BACKGROUND: Polymorphisms in the serine protease inhibitor gene serine peptidase inhibitor Kazal type 5 (SPINK5) and the serine protease kallikrein-related peptidase 7 gene (KLK7) appear to confer risk to eczema in some cohorts, but these findings have not been widely replicated. These genes encode proteins thought to be involved in the regulation of posttranslation processing of filaggrin (FLG), the strongest identified genetic risk factor for eczema to date. OBJECTIVES: We sought to clarify th...    »
 
Journal title abbreviation:
J Allergy Clin Immunol 
Year:
2008 
Journal volume:
122 
Journal issue:
Pages contribution:
560-8.e4 
Language:
eng 
Print-ISSN:
0091-6749 
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie ; Institut für Medizinische Statistik und Epidemiologie