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Document type:
journal article 
Author(s):
Kuhn, KA; Cozine, CL; Tomooka, B; Robinson, WH; Holers, VM 
Title:
Complement receptor CR2/CR1 deficiency protects mice from collagen-induced arthritis and associates with reduced autoantibodies to type II collagen and citrullinated antigens. 
Abstract:
Collagen-induced arthritis (CIA), a model of autoimmune inflammatory arthritis, depends upon complement activation and effective B cell responses. To determine the importance of complement receptors CR2/CR1 in CIA, the Cr2-/- genotype was backcrossed onto the DBA/1j strain. CIA was induced by immunization with bovine type II collagen in CFA on days 0 and 21. Cr2-/- mice demonstrated a significantly diminished arthritis severity, decreased antibodies to bovine and murine collagen, and a significa...    »
 
Journal title abbreviation:
Mol Immunol 
Year:
2008 
Journal volume:
45 
Journal issue:
10 
Pages contribution:
2808-19 
Language:
eng 
Print-ISSN:
0161-5890 
TUM Institution:
Institut für Medizinische Statistik und Epidemiologie