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Dokumenttyp:
journal article 
Autor(en):
Tietze, N; Pelisek, J; Philipp, A; Roedl, W; Merdan, T; Tarcha, P; Ogris, M; Wagner, E 
Titel:
Induction of apoptosis in murine neuroblastoma by systemic delivery of transferrin-shielded siRNA polyplexes for downregulation of Ran. 
Abstract:
The polymer, OEI-HD, based on beta-propionamide-cross-linked oligoethylenimine and its chemical transferrin conjugate were evaluated for siRNA delivery into murine Neuro2A neuroblastoma cells in vitro and in vivo. An 80% silencing of luciferase expression in neuroblastoma cells, stably transfected with a luciferase gene, was obtained using standard OEI-HD polyplexes or transferrin-conjugated shielded OEI-HD polyplexes. The Ras-related nuclear protein Ran was selected as a therapeutically relevan...    »
 
Zeitschriftentitel:
Oligonucleotides 
Jahr:
2008 
Band / Volume:
18 
Heft / Issue:
Seitenangaben Beitrag:
161-74 
Sprache:
eng 
Print-ISSN:
1545-4576 
TUM Einrichtung:
chirurgie