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Dokumenttyp:
journal article 
Autor(en):
Kastl, SP; Speidl, WS; Kaun, C; Katsaros, KM; Rega, G; Afonyushkin, T; Bochkov, VN; Valent, P; Assadian, A; Hagmueller, GW; Hoeth, M; de Martin, R; Ma, Y; Maurer, G; Huber, K; Wojta, J 
Titel:
In human macrophages the complement component C5a induces the expression of oncostatin M via AP-1 activation. 
Abstract:
OBJECTIVE: Macrophages produce the cytokine oncostatin M (OSM), which beside other functions is also involved in inflammation. The complement component C5a mobilizes and activates these cells at inflammatory sites. We examined the effect of C5a on OSM production in human monocytes and in human monocyte-derived macrophages. METHODS AND RESULTS: For macrophage transformation peripheral blood monocytes were cultivated for 8 to 10 days in the presence of human serum. C5a significantly increased in t...    »
 
Zeitschriftentitel:
Arterioscler Thromb Vasc Biol 
Jahr:
2008 
Band / Volume:
28 
Heft / Issue:
Seitenangaben Beitrag:
498-503 
Sprache:
eng 
Print-ISSN:
1079-5642 
TUM Einrichtung:
chirurgie