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Document type:
journal article 
Author(s):
Kastl, SP; Speidl, WS; Kaun, C; Katsaros, KM; Rega, G; Afonyushkin, T; Bochkov, VN; Valent, P; Assadian, A; Hagmueller, GW; Hoeth, M; de Martin, R; Ma, Y; Maurer, G; Huber, K; Wojta, J 
Title:
In human macrophages the complement component C5a induces the expression of oncostatin M via AP-1 activation. 
Abstract:
OBJECTIVE: Macrophages produce the cytokine oncostatin M (OSM), which beside other functions is also involved in inflammation. The complement component C5a mobilizes and activates these cells at inflammatory sites. We examined the effect of C5a on OSM production in human monocytes and in human monocyte-derived macrophages. METHODS AND RESULTS: For macrophage transformation peripheral blood monocytes were cultivated for 8 to 10 days in the presence of human serum. C5a significantly increased in t...    »
 
Journal title abbreviation:
Arterioscler Thromb Vasc Biol 
Year:
2008 
Journal volume:
28 
Journal issue:
Pages contribution:
498-503 
Language:
eng 
Print-ISSN:
1079-5642 
TUM Institution:
chirurgie