Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Frey, UH; Hauner, H; Jöckel, KH; Manthey, I; Brockmeyer, N; Siffert, W 
Titel:
A novel promoter polymorphism in the human gene GNAS affects binding of transcription factor upstream stimulatory factor 1, Galphas protein expression and body weight regulation. 
Abstract:
OBJECTIVES: Body weight regulation is under complex control involving the central nervous system and peripheral pathways. The beta-adrenoceptor Galphas protein system plays an important role in heart rate regulation and lipid mobilization suggesting a key role for the stimulatory G protein Galphas in body weight regulation. METHODS: We sequenced the whole GNAS promoter to identify a functional variant which results in altered Galphas expression. We genotyped 110 participants of a randomized plac...    »
 
Zeitschriftentitel:
Pharmacogenet Genomics 
Jahr:
2008 
Band / Volume:
18 
Heft / Issue:
Seitenangaben Beitrag:
141-51 
Sprache:
eng 
Print-ISSN:
1744-6872 
TUM Einrichtung:
hrungsmedizin