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Document type:
journal article 
Author(s):
Frey, UH; Hauner, H; Jöckel, KH; Manthey, I; Brockmeyer, N; Siffert, W 
Title:
A novel promoter polymorphism in the human gene GNAS affects binding of transcription factor upstream stimulatory factor 1, Galphas protein expression and body weight regulation. 
Abstract:
OBJECTIVES: Body weight regulation is under complex control involving the central nervous system and peripheral pathways. The beta-adrenoceptor Galphas protein system plays an important role in heart rate regulation and lipid mobilization suggesting a key role for the stimulatory G protein Galphas in body weight regulation. METHODS: We sequenced the whole GNAS promoter to identify a functional variant which results in altered Galphas expression. We genotyped 110 participants of a randomized plac...    »
 
Journal title abbreviation:
Pharmacogenet Genomics 
Year:
2008 
Journal volume:
18 
Journal issue:
Pages contribution:
141-51 
Language:
eng 
Print-ISSN:
1744-6872 
TUM Institution:
hrungsmedizin