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Dokumenttyp:
journal article 
Autor(en):
Samani, NJ; Braund, PS; Erdmann, J; Götz, A; Tomaszewski, M; Linsel-Nitschke, P; Hajat, C; Mangino, M; Hengstenberg, C; Stark, K; Ziegler, A; Caulfield, M; Burton, PR; Schunkert, H; Tobin, MD 
Titel:
The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol. 
Abstract:
Through genome-wide association studies, we have recently identified seven novel loci that confer a substantial increase in risk for coronary artery disease (CAD). Elucidating the mechanisms by which these loci affect CAD risk could have important clinical utility. Here, we investigated whether these loci act through mechanisms involving traditional cardiovascular risk factors. We genotyped 2,037 adult individuals from 520 nuclear families characterised for body mass index, waist-hip ratio, 24-h...    »
 
Zeitschriftentitel:
J Mol Med 
Jahr:
2008 
Band / Volume:
86 
Heft / Issue:
11 
Seitenangaben Beitrag:
1233-41 
Sprache:
eng 
Print-ISSN:
0946-2716 
TUM Einrichtung:
hrungsmedizin