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Document type:
journal article 
Author(s):
Frey, UH; Lieb, W; Erdmann, J; Savidou, D; Heusch, G; Leineweber, K; Jakob, H; Hense, HW; Löwel, H; Brockmeyer, NH; Schunkert, H; Siffert, W 
Title:
Characterization of the GNAQ promoter and association of increased Gq expression with cardiac hypertrophy in humans. 
Abstract:
AIMS: Transgenic mice with cardiac overexpression of Gq develop cardiac hypertrophy, apoptosis, and heart failure. Similar mechanisms may contribute to human left ventricular hypertrophy (LVH). However, mechanisms regulating transcription of the human GNAQ gene encoding the Gq protein are unknown and single-nucleotide polymorphisms have not been reported. METHODS AND RESULTS: We delineated essential elements for transcription in the human GNAQ promoter using reporter assays and showed promoter i...    »
 
Journal title abbreviation:
Eur Heart J 
Year:
2008 
Journal volume:
29 
Journal issue:
Pages contribution:
888-97 
Language:
eng 
Print-ISSN:
0195-668X 
TUM Institution:
hrungsmedizin