User: Guest  Login
Document type:
journal article 
Author(s):
Kintscher, U; Hartge, M; Hess, K; Foryst-Ludwig, A; Clemenz, M; Wabitsch, M; Fischer-Posovszky, P; Barth, TF; Dragun, D; Skurk, T; Hauner, H; Blüher, M; Unger, T; Wolf, AM; Knippschild, U; Hombach, V; Marx, N 
Title:
T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. 
Abstract:
BACKGROUND: Adipose tissue inflammation may play a critical role in the pathogenesis of insulin resistance (IR). The present study examined the role of lymphocytes in adipose tissue inflammation and IR. METHODS AND RESULTS: In a mouse model of obesity-mediated IR, high-fat diet (HFD) induced IR already after 5 weeks, which was associated with a marked T-lymphocyte infiltration in visceral adipose tissue. In contrast, recruitment of macrophages was delayed with an increase of MAC3-positive staini...    »
 
Journal title abbreviation:
Arterioscler Thromb Vasc Biol 
Year:
2008 
Journal volume:
28 
Journal issue:
Pages contribution:
1304-10 
Language:
eng 
Print-ISSN:
1079-5642 
TUM Institution:
hrungsmedizin