High noise levels lead to increased cytoplasmatic concentration of reactive oxygen species in the hair cells (HC) of the inner ear. In a guinea pig model, the therapeutic potential of the antioxidative agents α-lipoic acid, l-carnitine, and d-methionine for acoustic trauma was investigated. After 2.5 hours of exposure on 2 consecutive days to either broadband noise (BB) (115 dB SPL, n = 61 ears) or rock music (RM) (112 dB SPL, n = 62 ears), the antioxidative agents were injected intraperitoneally for 1 week. The auditory threshold was measured from 1.5 to 16 kHz prior to noise and at days 1, 3, 7, and 21 post-exposure using brainstem evoked response audiometry (BERA) and the distortion products of otoacoustic emissions (DPOAE). Both BB and RM damage the outer HC; RM also damages the inner HC. Partial recovery occurred during the first 3 days after exposure. Ultimately, it was demonstrated that none of the antioxidative agents utilized in this study show a therapeutic effect on acoustic trauma in the guinea pig after exposure to either BB or RM.
«High noise levels lead to increased cytoplasmatic concentration of reactive oxygen species in the hair cells (HC) of the inner ear. In a guinea pig model, the therapeutic potential of the antioxidative agents α-lipoic acid, l-carnitine, and d-methionine for acoustic trauma was investigated. After 2.5 hours of exposure on 2 consecutive days to either broadband noise (BB) (115 dB SPL, n = 61 ears) or rock music (RM) (112 dB SPL, n = 62 ears), the antioxidative agents were injected intraperitoneall...
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