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Document type:
journal article 
Author(s):
Diemer, C; Schneider, M; Seebach, J; Quaas, J; Frösner, G; Schätzl, HM; Gilch, S 
Title:
Cell type-specific cleavage of nucleocapsid protein by effector caspases during SARS coronavirus infection. 
Abstract:
The epidemic outbreak of severe acute respiratory syndrome (SARS) in 2003 was caused by a novel coronavirus (CoV), designated SARS-CoV. The RNA genome of SARS-CoV is complexed by the nucleocapsid protein (N) to form a helical nucleocapsid. Besides this primary function, N seems to be involved in apoptotic scenarios. We show that upon infection of Vero E6 cells with SARS-CoV, which elicits a pronounced cytopathic effect and a high viral titer, N is cleaved by caspases. In contrast, in SARS-CoV-in...    »
 
Journal title abbreviation:
J Mol Biol 
Year:
2008 
Journal volume:
376 
Journal issue:
Pages contribution:
23-34 
Language:
eng 
Print-ISSN:
0022-2836 
TUM Institution:
Institut für Virologie