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Dokumenttyp:
journal article 
Autor(en):
Diemer, C; Schneider, M; Seebach, J; Quaas, J; Frösner, G; Schätzl, HM; Gilch, S 
Titel:
Cell type-specific cleavage of nucleocapsid protein by effector caspases during SARS coronavirus infection. 
Abstract:
The epidemic outbreak of severe acute respiratory syndrome (SARS) in 2003 was caused by a novel coronavirus (CoV), designated SARS-CoV. The RNA genome of SARS-CoV is complexed by the nucleocapsid protein (N) to form a helical nucleocapsid. Besides this primary function, N seems to be involved in apoptotic scenarios. We show that upon infection of Vero E6 cells with SARS-CoV, which elicits a pronounced cytopathic effect and a high viral titer, N is cleaved by caspases. In contrast, in SARS-CoV-in...    »
 
Zeitschriftentitel:
J Mol Biol 
Jahr:
2008 
Band / Volume:
376 
Heft / Issue:
Seitenangaben Beitrag:
23-34 
Sprache:
eng 
Print-ISSN:
0022-2836 
TUM Einrichtung:
r Virologie