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Dokumenttyp:
journal article 
Autor(en):
Krammer, C; Suhre, MH; Kremmer, E; Diemer, C; Hess, S; Schätzl, HM; Scheibel, T; Vorberg, I 
Titel:
Prion protein/protein interactions: fusion with yeast Sup35p-NM modulates cytosolic PrP aggregation in mammalian cells. 
Abstract:
In mammalian prion diseases, an abnormally folded, aggregated form of the prion protein (PrP(Sc)) appears to catalyze a conformational switch of its cellular isoform (PrP(C)) to an aggregated state. A similar prion-like phenomenon has been reported for the Saccharomyces cerevisiae translation termination factor Sup35p that can adopt a self-propagating conformation. We have compared aggregation propensities of chimeric proteins derived from the Sup35p prion domain NM and PrP in vitro and in the c...    »
 
Zeitschriftentitel:
FASEB J 
Jahr:
2008 
Band / Volume:
22 
Heft / Issue:
Seitenangaben Beitrag:
762-73 
Sprache:
eng 
Print-ISSN:
0892-6638 
TUM Einrichtung:
r Virologie