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Document type:
journal article 
Author(s):
El-Gogo, S; Staib, C; Meyr, M; Erfle, V; Sutter, G; Adler, H 
Title:
Recombinant murine gammaherpesvirus 68 (MHV-68) as challenge virus to test efficacy of vaccination against chronic virus infections in the mouse model. 
Abstract:
Efficient vaccines against AIDS, Hepatitis C and other persistent virus infections are urgently needed. Vaccine development has been especially hampered by the lack of suitable small animal models to reliably test the protective capacity of candidate vaccines against such chronic viral infections. A natural mouse pathogen such as MHV-68 that persists lifelong after infection, appears to be a particularly promising candidate for a more relevant model system. Here, we investigated infections with...    »
 
Journal title abbreviation:
Vaccine 
Year:
2007 
Journal volume:
25 
Journal issue:
20 
Pages contribution:
3934-45 
Language:
eng 
Print-ISSN:
0264-410X 
TUM Institution:
Institut für Virologie