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Dokumenttyp:
journal article 
Autor(en):
Gilch, S; Kehler, C; Schätzl, HM 
Titel:
Peptide aptamers expressed in the secretory pathway interfere with cellular PrPSc formation. 
Abstract:
Prion diseases are rare and obligatory fatal neurodegenerative disorders caused by the accumulation of a misfolded isoform (PrPSc) of the host-encoded prion protein (PrPc). Prophylactic and therapeutic regimens against prion diseases are very limited. To extend such strategies we selected peptide aptamers binding to PrP from a combinatorial peptide library presented on the Escherichia coli thioredoxin A (trxA) protein as a scaffold. In a yeast two-hybrid screen employing full-length murine PrP (...    »
 
Zeitschriftentitel:
J Mol Biol 
Jahr:
2007 
Band / Volume:
371 
Heft / Issue:
Seitenangaben Beitrag:
362-73 
Sprache:
eng 
Print-ISSN:
0022-2836 
TUM Einrichtung:
r Virologie