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Document type:
journal article 
Author(s):
Maas, E; Geissen, M; Groschup, MH; Rost, R; Onodera, T; Schätzl, H; Vorberg, IM 
Title:
Scrapie infection of prion protein-deficient cell line upon ectopic expression of mutant prion proteins. 
Abstract:
Expression of the cellular prion protein (PrP(C)) is crucial for susceptibility to prions. In vivo, ectopic expression of PrP(C) restores susceptibility to prions and transgenic mice that express heterologous PrP on a PrP knock-out background have been used extensively to study the role of PrP alterations for prion transmission and species barriers. Here we report that prion protein knock-out cells can be rendered permissive to scrapie infection by the ectopic expression of PrP. The system was u...    »
 
Journal title abbreviation:
J Biol Chem 
Year:
2007 
Journal volume:
282 
Journal issue:
26 
Pages contribution:
18702-10 
Language:
eng 
Print-ISSN:
0021-9258 
TUM Institution:
Institut für Virologie