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Document type:
journal article 
Author(s):
Handisurya, A; Gilch, S; Winter, D; Shafti-Keramat, S; Maurer, D; Schätzl, HM; Kirnbauer, R 
Title:
Vaccination with prion peptide-displaying papillomavirus-like particles induces autoantibodies to normal prion protein that interfere with pathologic prion protein production in infected cells. 
Abstract:
Prion diseases are fatal neurodegenerative disorders caused by proteinaceous infectious pathogens termed prions (PrP(Sc)). To date, there is no prophylaxis or therapy available for these transmissible encephalopathies. Passive immunization with monclonal antibodies recognizing the normal host-encoded prion protein (PrP(C)) has been reported to abolish PrP(Sc) infectivity and to delay onset of disease. Because of established immunologic tolerance against the widely expressed PrP(C), active immuni...    »
 
Journal title abbreviation:
FEBS J 
Year:
2007 
Journal volume:
274 
Journal issue:
Pages contribution:
1747-58 
Language:
eng 
Print-ISSN:
1742-464X 
TUM Institution:
Institut für Virologie