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Document type:
journal article 
Author(s):
Lohner, K; Schnäbele, K; Daniel, H; Oesterle, D; Rechkemmer, G; Göttlicher, M; Wenzel, U 
Title:
Flavonoids alter P-gp expression in intestinal epithelial cells in vitro and in vivo. 
Abstract:
Flavonoids are secondary plant metabolites included in our diet but are also provided in a growing number of supplements. They are suggested to interact with intestinal transport systems including phospho-glycoprotein (P-gp) which mediates the efflux of a variety of xenobiotics back into the gut lumen. In human intestinal Caco-2 cells, we tested the effects of 14 different flavonoids on P-gp expression in vitro. Protein expression levels were quantified by Western blotting, flow cytometry, and r...    »
 
Journal title abbreviation:
Mol Nutr Food Res 
Year:
2007 
Journal volume:
51 
Journal issue:
Pages contribution:
293-300 
Language:
eng 
Print-ISSN:
1613-4125 
TUM Institution:
Institut für Toxikologie und Umwelthygiene